Description of Registration Technique for Barillot and Lemoine

Barillot and Lemoine [1] used a two-stage technique both for CT-to-MR and PET-to-MR registration. The first step is to perform an approximate registration of objects which are similar in each image, e.g., the head or the surface of the brain, with the choice of object being made a priori by examination of the images for the most suitable candidate. After automatically segmenting the object in the image volumes (the algorithm used depending on the feature to be segmented), a principal component matching method is applied, bringing the objects into an approximate alignment. The second stage is the application of a multiresolution Powell [2] algorithm which minimizes the Euclidean distance between the two surfaces given by a 5 x 5 x 5 chamfer mask. The total time taken for each registration was approximately 15 minutes using a Sun SPARCstation 20.

1. "Multimodal registration system for the fusion of MRI, CT, MEG, and 3D or stereotactic angiographic data", D. Lemoine, D. Liegeard, E. Lussot, and C. Barillot, Proc SPIE 1994, vol. 2164, pp. 46-56.

2. "An efficient method for finding the minimum of a function of several variables without calculating derivatives", M. J. D. Powell, Comput J 1964, vol. 7, pp. 155-163.

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